1.
Mem. Inst. Oswaldo Cruz
;
88(1): 155-8, jan.-mar. 1993. tab, ilus
Article
in English
| LILACS
| ID: lil-117665
ABSTRACT
Due to the narrow therapeutic range of theophyline, plasma concentrations of this drug are monitored in patients undergoing chronic therapy. Slow-release preparations avoid the fluctuations in plasma levels and improve patient compliance. In this study, we have compared the pharmacokinetic profiles of a theophylline slow-release tablet and a syrup form, when administered in multiple doses to healthy adult volunteers. The classification based upon releasing patterns is confirmed